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An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses.

Cell reports. Medicine

Hong JP, Reynoso GV, Andhey PS, Swain A, Turner JS, Boon ACM, Krammer F, Ellebedy AH, Zanini F, Artyomov M, Hickman HD, Diamond MS.
PMID: 32699843
Cell Rep Med. 2020 Jun 23;1(3). doi: 10.1016/j.xcrm.2020.100035.

CD137 is a costimulatory receptor expressed on natural killer cells, T cells, and subsets of dendritic cells. An agonistic monoclonal antibody (mAb) against CD137 has been used to reduce tumor burden or reverse autoimmunity in animal models and clinical...

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Hong JP, Reynoso GV, Andhey PS, et al. An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses. Cell Rep Med. 2020;1(3)doi: 10.1016/j.xcrm.2020.100035.
Hong, J. P., Reynoso, G. V., Andhey, P. S., Swain, A., Turner, J. S., Boon, A. C. M., Krammer, F., Ellebedy, A. H., Zanini, F., Artyomov, M., Hickman, H. D., & Diamond, M. S. (2020). An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses. Cell reports. Medicine, 1(3), . https://doi.org/10.1016/j.xcrm.2020.100035
Hong, Jun P, et al. "An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses." Cell reports. Medicine vol. 1,3 (2020). doi: https://doi.org/10.1016/j.xcrm.2020.100035
Hong JP, Reynoso GV, Andhey PS, Swain A, Turner JS, Boon ACM, Krammer F, Ellebedy AH, Zanini F, Artyomov M, Hickman HD, Diamond MS. An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses. Cell Rep Med. 2020 Jun 23;1(3). doi: 10.1016/j.xcrm.2020.100035. PMID: 32699843; PMCID: PMC7375459.
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DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden.

Cell reports. Medicine

Hsiehchen D, Hsieh A, Samstein RM, Lu T, Beg MS, Gerber DE, Wang T, Morris LGT, Zhu H.
PMID: 32676589
Cell Rep Med. 2020 Jun 23;1(3). doi: 10.1016/j.xcrm.2020.100034.

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, but prediction of their benefit is challenging. Neoantigens generated through impaired non-mismatch DNA repair may result in greater ICI activity. By analyzing 1,661 ICI-treated patients, we show that deletions and mutations...

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Hsiehchen D, Hsieh A, Samstein RM, et al. DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden. Cell Rep Med. 2020;1(3)doi: 10.1016/j.xcrm.2020.100034.
Hsiehchen, D., Hsieh, A., Samstein, R. M., Lu, T., Beg, M. S., Gerber, D. E., Wang, T., Morris, L. G. T., & Zhu, H. (2020). DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden. Cell reports. Medicine, 1(3), . https://doi.org/10.1016/j.xcrm.2020.100034
Hsiehchen, David, et al. "DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden." Cell reports. Medicine vol. 1,3 (2020). doi: https://doi.org/10.1016/j.xcrm.2020.100034
Hsiehchen D, Hsieh A, Samstein RM, Lu T, Beg MS, Gerber DE, Wang T, Morris LGT, Zhu H. DNA Repair Gene Mutations as Predictors of Immune Checkpoint Inhibitor Response beyond Tumor Mutation Burden. Cell Rep Med. 2020 Jun 23;1(3). doi: 10.1016/j.xcrm.2020.100034. PMID: 32676589; PMCID: PMC7365618.
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Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study.

Cell reports. Medicine

Collier DA, Assennato SM, Warne B, Sithole N, Sharrocks K, Ritchie A, Ravji P, Routledge M, Sparkes D, Skittrall J, Smielewska A, Ramsey I, Goel N, Curran M, Enoch D, Tassell R, Lineham M, Vaghela D, Leong C, Mok HP, Bradley J, Smith KGC, Mendoza V, Demiris N, Besser M, Dougan G, Lehner PJ, Siedner MJ, Zhang H, Waddington CS, Lee H, Gupta RK.
PMID: 32838340
Cell Rep Med. 2020 Aug 25;1(5):100062. doi: 10.1016/j.xcrm.2020.100062. Epub 2020 Jul 15.

There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined nasal and throat swabbing...

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Collier DA, Assennato SM, Warne B, et al. Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study. Cell Rep Med. 2020;1(5):100062doi: 10.1016/j.xcrm.2020.100062.
Collier, D. A., Assennato, S. M., Warne, B., Sithole, N., Sharrocks, K., Ritchie, A., Ravji, P., Routledge, M., Sparkes, D., Skittrall, J., Smielewska, A., Ramsey, I., Goel, N., Curran, M., Enoch, D., Tassell, R., Lineham, M., Vaghela, D., Leong, C., Mok, H. P., Bradley, J., Smith, K. G. C., Mendoza, V., Demiris, N., Besser, M., Dougan, G., Lehner, P. J., Siedner, M. J., Zhang, H., Waddington, C. S., Lee, H., Gupta, R. K. (2020). Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study. Cell reports. Medicine, 1(5), 100062. https://doi.org/10.1016/j.xcrm.2020.100062
Collier, Dami A, et al. "Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study." Cell reports. Medicine vol. 1,5 (2020): 100062. doi: https://doi.org/10.1016/j.xcrm.2020.100062
Collier DA, Assennato SM, Warne B, Sithole N, Sharrocks K, Ritchie A, Ravji P, Routledge M, Sparkes D, Skittrall J, Smielewska A, Ramsey I, Goel N, Curran M, Enoch D, Tassell R, Lineham M, Vaghela D, Leong C, Mok HP, Bradley J, Smith KGC, Mendoza V, Demiris N, Besser M, Dougan G, Lehner PJ, Siedner MJ, Zhang H, Waddington CS, Lee H, Gupta RK. Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study. Cell Rep Med. 2020 Aug 25;1(5):100062. doi: 10.1016/j.xcrm.2020.100062. Epub 2020 Jul 15. PMID: 32838340; PMCID: PMC7362826.
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Spatially resolved proteomics identify biomarkers from endometrial sentinel lymph nodes.

Cell reports. Medicine

Li R, Zhou S.
PMID: 34195676
Cell Rep Med. 2021 Jun 15;2(6):100283. doi: 10.1016/j.xcrm.2021.100283. eCollection 2021 Jun 15.

In this issue, Aboulouard et al. (2021) use spatially resolved shot-gun proteomics to characterize the sentinel lymph nodes (SLNs) of endometrial cancer patients at different pathological grades. They identify biomarkers that predict prognosis as well as tumor grade.

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Li R, Zhou S. Spatially resolved proteomics identify biomarkers from endometrial sentinel lymph nodes. Cell Rep Med. 2021;2(6):100283doi: 10.1016/j.xcrm.2021.100283.
Li, R., & Zhou, S. (2021). Spatially resolved proteomics identify biomarkers from endometrial sentinel lymph nodes. Cell reports. Medicine, 2(6), 100283. https://doi.org/10.1016/j.xcrm.2021.100283
Li, Renliang, and Zhou, Shengtao. "Spatially resolved proteomics identify biomarkers from endometrial sentinel lymph nodes." Cell reports. Medicine vol. 2,6 (2021): 100283. doi: https://doi.org/10.1016/j.xcrm.2021.100283
Li R, Zhou S. Spatially resolved proteomics identify biomarkers from endometrial sentinel lymph nodes. Cell Rep Med. 2021 Jun 15;2(6):100283. doi: 10.1016/j.xcrm.2021.100283. eCollection 2021 Jun 15. PMID: 34195676; PMCID: PMC8233646.
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Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients.

Cell reports. Medicine

Buehler PK, Zinkernagel AS, Hofmaenner DA, Wendel Garcia PD, Acevedo CT, Gómez-Mejia A, Mairpady Shambat S, Andreoni F, Maibach MA, Bartussek J, Hilty MP, Frey PM, Schuepbach RA, Brugger SD.
PMID: 33748789
Cell Rep Med. 2021 Apr 20;2(4):100229. doi: 10.1016/j.xcrm.2021.100229. Epub 2021 Mar 14.

The impact of secondary bacterial infections (superinfections) in coronavirus disease 2019 (COVID-19) is not well understood. In this prospective, monocentric cohort study, we aim to investigate the impact of superinfections in COVID-19 patients with acute respiratory distress syndrome. Patients...

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Buehler PK, Zinkernagel AS, Hofmaenner DA, et al. Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients. Cell Rep Med. 2021;2(4):100229doi: 10.1016/j.xcrm.2021.100229.
Buehler, P. K., Zinkernagel, A. S., Hofmaenner, D. A., Wendel Garcia, P. D., Acevedo, C. T., Gómez-Mejia, A., Mairpady Shambat, S., Andreoni, F., Maibach, M. A., Bartussek, J., Hilty, M. P., Frey, P. M., Schuepbach, R. A., & Brugger, S. D. (2021). Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients. Cell reports. Medicine, 2(4), 100229. https://doi.org/10.1016/j.xcrm.2021.100229
Buehler, Philipp K, et al. "Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients." Cell reports. Medicine vol. 2,4 (2021): 100229. doi: https://doi.org/10.1016/j.xcrm.2021.100229
Buehler PK, Zinkernagel AS, Hofmaenner DA, Wendel Garcia PD, Acevedo CT, Gómez-Mejia A, Mairpady Shambat S, Andreoni F, Maibach MA, Bartussek J, Hilty MP, Frey PM, Schuepbach RA, Brugger SD. Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients. Cell Rep Med. 2021 Apr 20;2(4):100229. doi: 10.1016/j.xcrm.2021.100229. Epub 2021 Mar 14. PMID: 33748789; PMCID: PMC7955928.
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A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.

Cell reports. Medicine

Raman S, Buongervino SN, Lane MV, Zhelev DV, Zhu Z, Cui H, Martinez B, Martinez D, Wang Y, Upton K, Patel K, Rathi KS, Navia CT, Harmon DB, Li Y, Pawel B, Dimitrov DS, Maris JM, Julien JP, Bosse KR.
PMID: 34337560
Cell Rep Med. 2021 Jul 21;2(7):100344. doi: 10.1016/j.xcrm.2021.100344. eCollection 2021 Jul 20.

Glypican 2 (GPC2) is a MYCN-regulated, differentially expressed cell-surface oncoprotein and target for immune-based therapies in neuroblastoma. Here, we build on GPC2's immunotherapeutic attributes by finding that it is also a highly expressed, MYCN-driven oncoprotein on small-cell lung cancers...

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Raman S, Buongervino SN, Lane MV, et al. A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med. 2021;2(7):100344doi: 10.1016/j.xcrm.2021.100344.
Raman, S., Buongervino, S. N., Lane, M. V., Zhelev, D. V., Zhu, Z., Cui, H., Martinez, B., Martinez, D., Wang, Y., Upton, K., Patel, K., Rathi, K. S., Navia, C. T., Harmon, D. B., Li, Y., Pawel, B., Dimitrov, D. S., Maris, J. M., Julien, J. P., & Bosse, K. R. (2021). A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell reports. Medicine, 2(7), 100344. https://doi.org/10.1016/j.xcrm.2021.100344
Raman, Swetha, et al. "A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope." Cell reports. Medicine vol. 2,7 (2021): 100344. doi: https://doi.org/10.1016/j.xcrm.2021.100344
Raman S, Buongervino SN, Lane MV, Zhelev DV, Zhu Z, Cui H, Martinez B, Martinez D, Wang Y, Upton K, Patel K, Rathi KS, Navia CT, Harmon DB, Li Y, Pawel B, Dimitrov DS, Maris JM, Julien JP, Bosse KR. A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med. 2021 Jul 21;2(7):100344. doi: 10.1016/j.xcrm.2021.100344. eCollection 2021 Jul 20. PMID: 34337560; PMCID: PMC8324494.
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Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine.

Cell reports. Medicine

Chaytow H, Faller KME, Huang YT, Gillingwater TH.
PMID: 34337562
Cell Rep Med. 2021 Jul 21;2(7):100346. doi: 10.1016/j.xcrm.2021.100346. eCollection 2021 Jul 20.

Spinal muscular atrophy (SMA) is a devastating childhood motor neuron disease that, in the most severe cases and when left untreated, leads to death within the first two years of life. Recent therapeutic advances have given hope to families...

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Chaytow H, Faller KME, Huang YT, et al. Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine. Cell Rep Med. 2021;2(7):100346doi: 10.1016/j.xcrm.2021.100346.
Chaytow, H., Faller, K. M. E., Huang, Y. T., & Gillingwater, T. H. (2021). Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine. Cell reports. Medicine, 2(7), 100346. https://doi.org/10.1016/j.xcrm.2021.100346
Chaytow, Helena, et al. "Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine." Cell reports. Medicine vol. 2,7 (2021): 100346. doi: https://doi.org/10.1016/j.xcrm.2021.100346
Chaytow H, Faller KME, Huang YT, Gillingwater TH. Spinal muscular atrophy: From approved therapies to future therapeutic targets for personalized medicine. Cell Rep Med. 2021 Jul 21;2(7):100346. doi: 10.1016/j.xcrm.2021.100346. eCollection 2021 Jul 20. PMID: 34337562; PMCID: PMC8324491.
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Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient.

Cell reports. Medicine

Zhu Z, Wang W, Lin F, Jordan T, Li G, Silverman S, Qiu S, Joy AA, Chen C, Hockley DL, Zhang X, Zhou Q, Postovit LM, Zhang X, Hou Y, Mackey JR, Li B, Wong GK.
PMID: 34755126
Cell Rep Med. 2021 Oct 19;2(10):100404. doi: 10.1016/j.xcrm.2021.100404. eCollection 2021 Oct 19.

Pathological examination is the gold standard for cancer diagnosis, and breast tumor cells are often found in clusters. We report a case study on one triple-negative breast cancer (TNBC) patient, analyzing tumor development, metastasis, and prognosis with simultaneous DNA...

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Zhu Z, Wang W, Lin F, et al. Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient. Cell Rep Med. 2021;2(10):100404doi: 10.1016/j.xcrm.2021.100404.
Zhu, Z., Wang, W., Lin, F., Jordan, T., Li, G., Silverman, S., Qiu, S., Joy, A. A., Chen, C., Hockley, D. L., Zhang, X., Zhou, Q., Postovit, L. M., Zhang, X., Hou, Y., Mackey, J. R., Li, B., & Wong, G. K. (2021). Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient. Cell reports. Medicine, 2(10), 100404. https://doi.org/10.1016/j.xcrm.2021.100404
Zhu, Zhongyi, et al. "Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient." Cell reports. Medicine vol. 2,10 (2021): 100404. doi: https://doi.org/10.1016/j.xcrm.2021.100404
Zhu Z, Wang W, Lin F, Jordan T, Li G, Silverman S, Qiu S, Joy AA, Chen C, Hockley DL, Zhang X, Zhou Q, Postovit LM, Zhang X, Hou Y, Mackey JR, Li B, Wong GK. Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient. Cell Rep Med. 2021 Oct 19;2(10):100404. doi: 10.1016/j.xcrm.2021.100404. eCollection 2021 Oct 19. PMID: 34755126; PMCID: PMC8561166.
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Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men.

Cell reports. Medicine

Søberg S, Löfgren J, Philipsen FE, Jensen M, Hansen AE, Ahrens E, Nystrup KB, Nielsen RD, Sølling C, Wedell-Neergaard AS, Berntsen M, Loft A, Kjær A, Gerhart-Hines Z, Johannesen HH, Pedersen BK, Karstoft K, Scheele C.
PMID: 34755128
Cell Rep Med. 2021 Oct 11;2(10):100408. doi: 10.1016/j.xcrm.2021.100408. eCollection 2021 Oct 19.

The Scandinavian winter-swimming culture combines brief dips in cold water with hot sauna sessions, with conceivable effects on body temperature. We study thermogenic brown adipose tissue (BAT) in experienced winter-swimming men performing this activity 2-3 times per week. Our...

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Søberg S, Löfgren J, Philipsen FE, et al. Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men. Cell Rep Med. 2021;2(10):100408doi: 10.1016/j.xcrm.2021.100408.
Søberg, S., Löfgren, J., Philipsen, F. E., Jensen, M., Hansen, A. E., Ahrens, E., Nystrup, K. B., Nielsen, R. D., Sølling, C., Wedell-Neergaard, A. S., Berntsen, M., Loft, A., Kjær, A., Gerhart-Hines, Z., Johannesen, H. H., Pedersen, B. K., Karstoft, K., & Scheele, C. (2021). Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men. Cell reports. Medicine, 2(10), 100408. https://doi.org/10.1016/j.xcrm.2021.100408
Søberg, Susanna, et al. "Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men." Cell reports. Medicine vol. 2,10 (2021): 100408. doi: https://doi.org/10.1016/j.xcrm.2021.100408
Søberg S, Löfgren J, Philipsen FE, Jensen M, Hansen AE, Ahrens E, Nystrup KB, Nielsen RD, Sølling C, Wedell-Neergaard AS, Berntsen M, Loft A, Kjær A, Gerhart-Hines Z, Johannesen HH, Pedersen BK, Karstoft K, Scheele C. Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men. Cell Rep Med. 2021 Oct 11;2(10):100408. doi: 10.1016/j.xcrm.2021.100408. eCollection 2021 Oct 19. PMID: 34755128; PMCID: PMC8561167.
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Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma.

Cell reports. Medicine

Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS.
PMID: 34755131
Cell Rep Med. 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. eCollection 2021 Oct 19.

Neoadjuvant PD-1 blockade may be efficacious in some individuals with high-risk, resectable oral cavity head and neck cancer. To explore correlates of response patterns to neoadjuvant nivolumab treatment and post-surgical recurrences, we analyzed longitudinal tumor and blood samples in...

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Liu S, Knochelmann HM, Lomeli SH, et al. Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Cell Rep Med. 2021;2(10):100411doi: 10.1016/j.xcrm.2021.100411.
Liu, S., Knochelmann, H. M., Lomeli, S. H., Hong, A., Richardson, M., Yang, Z., Lim, R. J., Wang, Y., Dumitras, C., Krysan, K., Timmers, C., Romeo, M. J., Krieg, C., O'Quinn, E. C., Horton, J. D., Dubinett, S. M., Paulos, C. M., Neskey, D. M., & Lo, R. S. (2021). Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Cell reports. Medicine, 2(10), 100411. https://doi.org/10.1016/j.xcrm.2021.100411
Liu, Sixue, et al. "Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma." Cell reports. Medicine vol. 2,10 (2021): 100411. doi: https://doi.org/10.1016/j.xcrm.2021.100411
Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS. Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma. Cell Rep Med. 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. eCollection 2021 Oct 19. PMID: 34755131; PMCID: PMC8561238.
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Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms.

Cell reports. Medicine

Shen Z, Du W, Perkins C, Fechter L, Natu V, Maecker H, Rowley J, Gotlib J, Zehnder J, Krishnan A.
PMID: 34755136
Cell Rep Med. 2021 Oct 19;2(10):100425. doi: 10.1016/j.xcrm.2021.100425. eCollection 2021 Oct 19.

Predicting disease progression remains a particularly challenging endeavor in chronic degenerative disorders and cancer, thus limiting early detection, risk stratification, and preventive interventions. Here, profiling the three chronic subtypes of myeloproliferative neoplasms (MPNs), we identify the blood platelet transcriptome...

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Shen Z, Du W, Perkins C, et al. Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. Cell Rep Med. 2021;2(10):100425doi: 10.1016/j.xcrm.2021.100425.
Shen, Z., Du, W., Perkins, C., Fechter, L., Natu, V., Maecker, H., Rowley, J., Gotlib, J., Zehnder, J., & Krishnan, A. (2021). Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. Cell reports. Medicine, 2(10), 100425. https://doi.org/10.1016/j.xcrm.2021.100425
Shen, Zhu, et al. "Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms." Cell reports. Medicine vol. 2,10 (2021): 100425. doi: https://doi.org/10.1016/j.xcrm.2021.100425
Shen Z, Du W, Perkins C, Fechter L, Natu V, Maecker H, Rowley J, Gotlib J, Zehnder J, Krishnan A. Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. Cell Rep Med. 2021 Oct 19;2(10):100425. doi: 10.1016/j.xcrm.2021.100425. eCollection 2021 Oct 19. PMID: 34755136; PMCID: PMC8561315.
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Perspectives on the role of brown adipose tissue in human body temperature and metabolism.

Cell reports. Medicine

Scheele C.
PMID: 34755138
Cell Rep Med. 2021 Oct 19;2(10):100427. doi: 10.1016/j.xcrm.2021.100427. eCollection 2021 Oct 19.

In this Backstory, Camilla Scheele shares the journey of her group's research on human brown adipose tissue leading up to the study of winter swimmers' thermoregulation and energy expenditure (https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(21)00266-4) appearing in this issue of

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Scheele C. Perspectives on the role of brown adipose tissue in human body temperature and metabolism. Cell Rep Med. 2021;2(10):100427doi: 10.1016/j.xcrm.2021.100427.
Scheele, C. (2021). Perspectives on the role of brown adipose tissue in human body temperature and metabolism. Cell reports. Medicine, 2(10), 100427. https://doi.org/10.1016/j.xcrm.2021.100427
Scheele, Camilla. "Perspectives on the role of brown adipose tissue in human body temperature and metabolism." Cell reports. Medicine vol. 2,10 (2021): 100427. doi: https://doi.org/10.1016/j.xcrm.2021.100427
Scheele C. Perspectives on the role of brown adipose tissue in human body temperature and metabolism. Cell Rep Med. 2021 Oct 19;2(10):100427. doi: 10.1016/j.xcrm.2021.100427. eCollection 2021 Oct 19. PMID: 34755138; PMCID: PMC8561320.
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